Thyroid Function in Thyroid Carcinoma: A 5-year Retrospective Analysis
Philippine Journals Online
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| Title |
Thyroid Function in Thyroid Carcinoma: A 5-year Retrospective Analysis
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| Creator |
Suzette S Quiaoit; Clinical Fellow, Section of Endocrinology, Diabetes & Metabolism, St. Luke's Medical Center
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| Subject |
Endocrinology
Primary thyroid carcinoma; thyroid stimulating hormone; fine needle aspiration biopsy |
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| Description |
Background: Several studies investigated the behavior of thyroid stimulating hormone (TSH) among patients with documented thyroid carcinoma. Elevations of TSH are commonly seen and only a fraction of thyroid carcinomas present with low TSH levels. Objective: To describe the thyroid function in thyroid carcinomas. Setting: St. Lukes's Medical Center , Quezon City Philippines (Tertiary Institution) Design: Retrospective study Patients and Methods: Charts of medical records of patients diagnosed with primary thyroid carcinoma on routine biopsy, fine needle aspiration biopsy or frozen section from 2002 to 2006 were reviewed. Pertinent data such as the sex, age in years, provincial location; pertinent medical history such as previous history of head and neck radiation, family history of thyroid cancer, family history of multiple endocrine neoplasia (MEN-II); history of dysphonia/dysphagia; physical exam findings; pre-operative TSH and its interpretation; ultrasonographic assessment; official tissue biopsy results; TNM staging and overall tumor stage; and extent of surgery done. Comparison of categorical variables was done using Fisher Exact test and Kruskal Wallis ANOVA for mean TSH values across histologic types. All comparisons with p-values <.05 were considered significant. Results: A total of 400 patients were analyzed. There was slight female predominance, with a mean age of 44 years (range 14-86), residing mostly in Metro Manila, with a family history of MEN-II in 14% and medullary carcinoma in 2%. Papillary carcinoma and follicular CA were the most common histologic types. Most underwent total thyroidectomy with neck lymph node dissection in 63%. Mean TSH values did not statistically differ across the histologic types of cancer (p=.91). Majority (78%) had normal TSH (0.4-4.65 mIU/L) despite tumor size (p=.039) and nodal involvement (p=.035). Values of TSH did not statistically vary with metastasis and overall staging (p=.24, p=.63 respectively). Conclusion: Normal TSH levels were commonly seen in this sample of thyroid carcinomas. TSH determination in thyroid carcinoma guide clinicians regarding suppressive thyroid hormone therapy. Disclosure Statement: The authors have nothing to disclose. Keywords: Primary thyroid carcinoma; thyroid stimulating hormone; fine needle aspiration biopsy DOI: 10.3860/pjim.v47i2.1644 Phil. J. Internal Medicine, 47: 65-70, March-April, 2009
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| Publisher |
The Philippine College of Physicians
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| Contributor |
—
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| Date |
2010-07-23
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| Type |
Peer-Reviewed Article
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| Format |
application/pdf
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| Identifier |
http://www.philjol.info/index.php/PJIM/article/view/1644
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| Source |
Philippine Journal of Internal Medicine; Vol 47, No 2 (2009); 65-70
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| Language |
en
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| Coverage |
Philippines
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