Efek Toksin T-2 terhadap Perkembangan Embrio Praimplantasi dan Fetus Mencit Swiss Webster

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Title Efek Toksin T-2 terhadap Perkembangan Embrio Praimplantasi dan Fetus Mencit Swiss Webster
 
Creator AGUS HARYONO
TIEN WIATI SURJONO
SRI SUDARWATI
 
Subject Fusarium tricintum, T-2 toxin, mycotoxin, preimplantation embryos, embryotoxic
 
Description T-2 toxin is a toxic and teratogenic mycotoxin produced by Fusarium tricintum which may contaminate cereal, seed,and food. The aim of this research is to find out the effects of T-2 Toxin on preimplantion embryos and fetuses of SwissWebster mice. Pregnant female of Swiss Webster mice on 0 or 2 day of gestation was injected intraperitoneally with T-2toxin at doses 0.05 or 0.10 mg/kg body weight (bw) and the dam was observed at 3.5 and 18 days of gestation. At 0 day ofgestation, embryos were arrested at one to eight cell and uncompacted morulae stages (P < 0.01) compared to control, inboth 0.05 and 0.10 mg/kg bw doses. The cell numbers of late blastocyst at all treated groups were decreased significantlycompared to control. At 2 day of gestation, most of embryos were arrested on compacted morulae stage at dose 0.10 mg/kgbw (P < 0.01), the late blastocyst and its cell number were dose-dependently decreased. The live fetuses decreasedsignificantly at all dose of T-2 toxin. No external malformation occurred in the fetuses. Results showed that T-2 toxingiven at preimplantation stages inhibited development of preimplantation embryos as indicated by decreased number oflive fetuses. Therefore, it was grouped as embryotoxic agent but those dosages did not cause malformation of the externalappearance of Swiss Webster mice fetuses
 
Publisher —
 
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Date 2008-01-25
 
Type Peer-reviewed Article
 
Format application/pdf
 
Identifier http://www.ijonline.net/index.php/HAYATI/article/view/141
 
Source HAYATI, Journal of Biosciences; Vol 14, No 1 (2007)
 
Language en