Solution Properties and Phase Behavior of Ammonium Hexylene Octyl Succinate in Water and Water-Oil System
Bangladesh Journals Online
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| Title |
Solution Properties and Phase Behavior of Ammonium Hexylene Octyl Succinate in Water and Water-Oil System
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| Creator |
Md. Hamidul Kabir; Department of Applied Chemistry & Chemical Technology, University of Dhaka, Dhaka-1000
Ravshan Makhkamov; Surfactant Laboratory, Institute of General & Inorganic Chemistry, Academy of Science, 77a, Abdullaev str., 700170, Tashkent, Uzbekistan Shaila Kabir; Department of Pharmacy, The University of Asia Pacific, House-73, Road-5A, Dhanmondi R/A, Dhaka-1209 |
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| Subject |
Pharmacy
Ammonium hexylene octyl succinate; mixed surfactant; lamellar liquid crystal; middle-phase microemulsion |
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| Description |
The solution properties and phase behavior of ammonium hexylene octyl succinate (HOS) was investigated in water and water-oil system. The critical micelle concentration (CMC) of HOS is lower than that of anionic surfactants having same carbon number in the lipophilic part. The phase diagrams of a water/ HOS system and water/ HOS/ C10EO8/ dodecane system were also constructed. Above critical micelle concentration, the surfactant forms a normal micellar solution (Wm) at a low surfactant concentration whereas a lamellar liquid crystalline phase (La) dominates over a wide region through the formation of a two-phase region (La+W) in the binary system. The lamellar phase is arranged in the form of a biocompatible vesicle which is very significant for the drug delivery system. The surfactant tends to be hydrophilic when it is mixed with C10EO8 and a middle-phase microemulsion (D) is appeared in the water-surfactant-dodecane system where both the water and oil soluble drug ingredient can be incorporated in the form of a dispersion. Hence, mixing can tune the hydrophile-lipophile properties of the surfactant.
Key words: Ammonium hexylene octyl succinate, mixed surfactant, lamellar liquid crystal, middle-phase microemulsion.
Dhaka Univ. J. Pharm. Sci. Vol.3(1-2) 2004
The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website
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| Publisher |
Dhaka University
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| Date |
2007-06-14
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| Type |
—
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| Identifier |
http://www.banglajol.info/index.php/JPharma/article/view/183
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| Source |
Dhaka University Journal of Pharmaceutical Sciences; Vol 3, No 1 (2004)
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| Language |
en
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