Effect of Electrolytes on Release of Diclofenac Sodium from Agarose Beads
Bangladesh Journals Online
View Archive Info| Field | Value | |
| Title |
Effect of Electrolytes on Release of Diclofenac Sodium from Agarose Beads
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| Creator |
Ishrat Nimmi; Department of Pharmacy, The University of Asia Pacific, Dhaka-1209
Jakir Ahmed Chowdhury; Department of Pharmacy, The University of Asia Pacific, Dhaka-1209 Mia Mohammad Dulal; Julphar Gulf Pharmaceutical Ltd, R. A. K. UAE Md. Selim Reza; Faculty of Pharmacy, University of Dhaka, Dhaka-1000 |
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| Subject |
Pharmacy
Diclofenac Na; Agarose bead; Electrolyte |
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| Description |
Diclofenac sodium loaded agarose beads were prepared and release profile of Diclofenac Sodium was investigated. Beads were prepared by dropping a hot aqueous agar solution into a beaker of chilled Paraffin oil and water. Water was made acidic to the pH of 1.65 using concentrated hydrochloric acid to reduce the prior diffusion of Diclofenac sodium into preparatory vehicle. Upon drying, the beads shrank and their dimensions were changed. In-vitro drug dissolution studies were carried out in distilled water. The release profile was found to be a function of polymer load and electrolytes incorporation into the beads. Increasing the polymer load decreased the rate and extent of drug release due to increased thickness and reduced the porosity of the system. Incorporation of mono & divalent metal salts by abating the amount of agarose in the formulations increased the release rate of the drug.
Key words: Diclofenac Na, Agarose bead, Electrolyte
Dhaka Univ. J. Pharm. Sci. Vol.4(2) 2005
The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website
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| Publisher |
Dhaka University
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| Date |
2007-06-18
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| Type |
—
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| Identifier |
http://www.banglajol.info/index.php/JPharma/article/view/213
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| Source |
Dhaka University Journal of Pharmaceutical Sciences; Vol 4, No 2 (2005)
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| Language |
en
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