Soluble Drug Theophylline Sodium Glycinate from Different Suppository Bases
Bangladesh Journals Online
View Archive Info| Field | Value | |
| Title |
Soluble Drug Theophylline Sodium Glycinate from Different Suppository Bases
|
|
| Creator |
Faruk Ahmed; Department of Pharmacy, The University of Asia Pacific, Dhaka - 1209
SM Ashraful Islam; Department of Pharmacy, The University of Asia Pacific, Dhaka - 1209 Mohiuddin Abdul Quadir; Department of Pharmacy, The University of Asia Pacific, Dhaka - 1209 Md. Selim Reza; aculty of Pharmacy, University of Dhaka, Dhaka - 1000 |
|
| Subject |
Pharmacy
Theophylline sodium glycinate; Suppositories; In vitro release |
|
| Description |
Theophylline Sodium Glycinate (TSG) loaded lipid-based suppositories were prepared and the effects of suppository bases and release modifiers (PEG 1500 and HPMC 15 cps) on in vitro release of TSG were investigated. Suppositories containing 300 mg TSG were prepared by fusion method. Bees wax, Carnauba wax, Stearic acid and PEG 4000 were used as hydrophobic bases. In vitro dissolution was carried out in aqueous and buffered media of pH 6.8 for 2 hours. The results showed that, the release rate of TSG is considerably slow from beeswax, carnauba wax and stearic acid based devices. However, substantial TSG release was observed from PEG 4000 based systems. Incorporation of PEG 1500 in beeswax, carnauba wax and stearic acid based suppositories increased the rate and extent of TSG release in buffer media. Inclusion of HPMC 15 cps in PEG 4000 loaded suppositories released TSG at a faster rate. Drug release was linear for all the formulation except PEG 4000 systems, which released drug in a biphasic pattern both in aqueous and buffered environment. Rate and extent of drug release was found to be a function of pH of the dissolution media.
Key words: Theophylline sodium glycinate, Suppositories, In vitro release
Dhaka Univ. J. Pharm. Sci. Vol.3(1-2) 2004
The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website
|
|
| Publisher |
Dhaka University
|
|
| Date |
2007-06-14
|
|
| Type |
—
|
|
| Identifier |
http://www.banglajol.info/index.php/JPharma/article/view/182
|
|
| Source |
Dhaka University Journal of Pharmaceutical Sciences; Vol 3, No 1 (2004)
|
|
| Language |
en
|
|