Studies on Bio-adhesion of Matrix Tablets: I. Release Profile of Theophylline Anhydrous
Bangladesh Journals Online
View Archive Info| Field | Value | |
| Title |
Studies on Bio-adhesion of Matrix Tablets: I. Release Profile of Theophylline Anhydrous
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| Creator |
Md. Shamsuddin; Department of Pharmacy, The University of Asia Pacific, Dhaka-1209
Parvin Akter; Department of Pharmacy, The University of Asia Pacific, Dhaka-1209 Md. Ziaur Rahman Khan; Faculty of Pharmacy, University of Dhaka, Dhaka-1000 Jakir Ahmed Chowdhury; Faculty of Pharmacy, University of Dhaka, Dhaka-1000 Md. Selim Reza; Faculty of Pharmacy, University of Dhaka, Dhaka-1000 |
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| Subject |
Pharmacy
Bio-adhesion; Release profile; theophylline anhydrous |
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| Description |
Controlled release matrix tablets of theophylline anhydrous were designed with different types of bioadhesive polymers. HPMC 15 cps and 50 cps, Na-CMC, Gelatin, Xanthun gum and PVP K-30 were selected to formulate matrix tablets. Tablets of theophylline were prepared by direct compression method and were subjected to in vitro drug dissolution for 8 hrs in a gastric fluid media by using thermal shaker with a shaking speed of 50 rpm at a temperature of 37 ± 0.5°C. The in vitro release study as well as retention time of bioadhesive tablets on mucous membrane were investigated to develop a bioadhesive polymer based controlled release delivery system and to evaluate the performance of such delivery device. Na-CMC, HPMC and Xanthan gum based tablets showed greater bio-adhesive strength where as gelatin and PVP K-30 based tablets showed poor bioadhesive strength. Na-CMC and Xanthun gum loaded tablets were not discharged from the mucous membrane and these tablets were fully dissolved in the gastric fluid. Xanthan gum, Na-CMC and HPMC based formulation showed nearly zero-order release. On the contrary, gelatin and PVP K-30 based formulation showed a burst release within one hour of dissolution.
Key words: Bio-adhesion, Release profile, theophylline anhydrous.
Dhaka Univ. J. Pharm. Sci. Vol.5(1-2) 2006
The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website
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| Publisher |
Dhaka University
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| Date |
2007-06-20
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| Type |
—
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| Format |
application/pdf
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| Identifier |
http://www.banglajol.info/index.php/JPharma/article/view/226
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| Source |
Dhaka University Journal of Pharmaceutical Sciences; Vol 5, No 1 (2006); 33-37
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| Language |
en
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