Novel Floating Pulsatile Approach for Chronotherapeutic Release of Indomethacin

Bangladesh Journals Online

View Archive Info
 
 
Field Value
 
Title Novel Floating Pulsatile Approach for Chronotherapeutic Release of Indomethacin
 
Creator Shaji Jessy; Prin. K. M. Kundnani College of Pharmacy, Mumbai
Patole Vishal; Prin. K. M. Kundnani College of Pharmacy, Mumbai
 
Subject Pharmacy
Floating-pulsatile drug delivery; Chronotherapeutic release; Indomethacin; Pellets; Rheumatoid arthritis
 
Description The main objective of the present study was to develop a multiple-unit, floating-pulsatile drug delivery system for obtaining no drug release during floating and in the proximal small intestine followed by pulsed, rapid drug release in distal small intestine to achieve chronotherapeutic release of indomethacin. The system developed consists of drug containing core pellets prepared by extrusion-spheronization process, which were coated with an inner pH-dependent layer of Eudragit S100 and outer effervescent layer of sodium bicarbonate and HPMC K100M. Pellets showed instantaneous floating with no drug release in acidic medium followed by pulsed drug release in basic medium. Concentration of HPMC K100M and layering level of effervescent agent significantly affected performance of pellets. The system showed excellent lag phase followed by burst release in the distal small intestine which gives site and time specific delivery of indomethacin acting as per chronotherapy of rheumatoid arthritis. Key words: Floating-pulsatile drug delivery, Chronotherapeutic release, Indomethacin, Pellets, Rheumatoid arthritis. Dhaka Univ. J. Pharm. Sci. 6(1): 37-41, 2007 (June) The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website
 
Publisher Dhaka University
 
Date 2007-08-09
 
Type —
 
Format application/pdf
 
Identifier http://www.banglajol.info/index.php/JPharma/article/view/341
 
Source Dhaka University Journal of Pharmaceutical Sciences; Vol 6, No 1 (2007); 37-41
 
Language en
 
Coverage b