Evaluation of In vitro Antimicrobial and In vivo Cytotoxic Properties of Peroxo Coordination Complexes of Mg(II), Mn(II), Fe(II) & Ni(II)
Bangladesh Journals Online
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| Title |
Evaluation of In vitro Antimicrobial and In vivo Cytotoxic Properties of Peroxo Coordination Complexes of Mg(II), Mn(II), Fe(II) & Ni(II)
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| Creator |
Kudrat e Zahan; Department of Chemistry , University of Rajshahi, Rajshahi-6205
MD. Shamin Hossain; Department of Chemistry , University of Rajshahi, Rajshahi-6205 Shuranjan Sarkar; Department of Chemistry , University of Rajshahi, Rajshahi-6205 Md. Mukhlesur Rahman; Department of Pharmacy, University of Rajshahi, Rajshahi-6205 Md. Akhter Farooque; Department of Chemistry , University of Rajshahi, Rajshahi-6205 Md. Najmul Karim; Department of Pharmacy, University of Rajshahi, Rajshahi-6205 Laizuman Nahar; Department of Pharmacy, University of Rajshahi, Rajshahi-6205 Md. Aslam Hossain; Department of Pharmacy, University of Rajshahi, Rajshahi-6205 |
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| Subject |
Pharmacy
Peroxo coordination complexes; Antimicrobial activity; antifungal activity; cytotoxic activity |
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| Description |
Six newly synthesized nickel peroxo coordination complexes, [Mg2(2-ap)2(O2)(OH), A], [Mn(2-ap) (ED)(O2), B], [Fe(2-ab)(ED)(O2), C], [Fe(2-ap)(ED)(O2), D], [Ni2(2-ab)2(O2)(OH), E] and [Ni2(2-ap)2(O2)(OH), F] showed significant antibacterial and antifungal activities. The minimum inhibitory concentrations (MIC) of these compounds were found in the range of 8-128 µg/ml. Among these compounds, F showed maximum cytotoxicity (LC50 = 3.62 µg/ml) in brine shrimp lethality bioassay.
Key words: Peroxo coordination complexes; Antimicrobial activity; antifungal activity; cytotoxic activity.
Dhaka Univ. J. Pharm. Sci. Vol.3(1-2) 2004
The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website
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| Publisher |
Dhaka University
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| Date |
2007-06-14
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—
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| Identifier |
http://www.banglajol.info/index.php/JPharma/article/view/184
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| Source |
Dhaka University Journal of Pharmaceutical Sciences; Vol 3, No 1 (2004)
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| Language |
en
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