Synthesis and Biological Activities of 2-Substituted Benzimidazole-Metal Complexes
Bangladesh Journals Online
View Archive Info| Field | Value | |
| Title |
Synthesis and Biological Activities of 2-Substituted Benzimidazole-Metal Complexes
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| Creator |
Md Afzal Azam; Department of Pharmaceutical Chemistry, J. S. S., College of Pharmacy, Ootacamund-643001, Tamil Nadu
BRP Kumar; Department of Pharmaceutical Chemistry, J. S. S., College of Pharmacy, Ootacamund-643001, Tamil Nadu R Mazumdar; Department of Pharmaceutical Chemistry, J. S. S., College of Pharmacy, Ootacamund-643001, Tamil Nadu B Suresh; Department of Pharmaceutical Chemistry, J. S. S., College of Pharmacy, Ootacamund-643001, Tamil Nadu |
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| Subject |
Pharmacy
Cu(II) complexes; Co(II) complexes; Benzimidazoles; Antitumor activity — |
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| Description |
A series of copper(II) and cobalt(II) coordination compounds with 2-substituted benzimidazole derived monodentate and bidentate ligands have been prepared and characterized by microanalysis, IR and UV-Vis spectroscopy. Synthesized metal complexes have been screened for their in vitro antioxidant and antitumor activity. The complex 4a showed significant nitric oxide free radical scavenging activity (IC50 65μg/ml), while 3i and 3g showed potent superoxide dismutase activity with IC50 of 0.26 and 0.28 μM respectively. In vitro cytotoxicity study with human breast MCF-7 and CNS SF 268 cancer cell lines showed that the most active 2-benzyl-1H-benzimidazole Cu(II) complex 3a inhibited the growth of cancer cells at 20 μM concentration. Keywords: Cu(II) complexes; Co(II) complexes; Benzimidazoles; Antitumor activity. DOI: 10.3329/dujps.v8i2.6027 Dhaka Univ. J. Pharm. Sci. 8(2): 131-140, 2009 (December)
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| Publisher |
Dhaka University
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| Contributor |
—
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| Date |
2010-09-06
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| Type |
—
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| Format |
application/pdf
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| Identifier |
http://www.banglajol.info/index.php/JPharma/article/view/6027
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| Source |
Dhaka University Journal of Pharmaceutical Sciences; Vol 8, No 2 (2009); 131-140
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| Language |
en
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| Coverage |
India
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